PNC-27 30mg
Researched Benefits:
- Facilitates analysis of p53-derived peptide binding to the HDM2-receptor signaling complex
- Supports investigation into membrane-permeabilization mechanisms within p53-deficient cellular assay models
- Enables research on HDM2-mediated E3 ubiquitin ligase inhibition and proteasomal degradation
- Useful for evaluating selective peptide-induced necrosis through specific trans-membrane helical interactions
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Description
Description
PNC-27 30mg is a chimeric research peptide explored for its potent, selective cytotoxicity against malignant cells. Engineered from the HDM-2-binding domain of p53 fused to a cell-penetrating leader sequence, PNC-27 disrupts tumor-cell membranes while leaving healthy cells largely unharmed. Synthesized from premium raw materials and rigorously purified, our PNC-27 offers exceptional consistency and reliability for advanced oncological investigations.
Key Features:
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Manufactured under stringent GMP-compliant conditions to maximize purity and bioactivity.
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Each lot is subjected to comprehensive HPLC and mass-spectrometry analysis for quality assurance.
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Supplied as a lyophilized powder to preserve structural integrity during storage and transport.
Applications:
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Elucidating mechanisms of HDM-2 interaction and membrane pore formation in tumor cells.
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Assessing selective cytotoxicity and necrosis induction across diverse cancer lines.
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Investigating synergistic potential with existing chemotherapeutic agents.
Specifications and Documentation
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Material Safety Data Sheet (MSDS):Â Coming Soon.
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Handling and Storage Instructions:Â Coming Soon.
PNC-27 30mg provides researchers with a precise tool to interrogate targeted anti-cancer strategies, paving the way for deeper insights into tumor-selective therapies.
Additional information
| CAS No. | 1159861-00-3 |
|---|---|
| Purity | ≥99% |
| Sequence | Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly |
| Molecular Formula | C188H293N53O44S |
| Molecular Weight | 4031.73 g/mol |
| Applications | Oncology studies, tumor necrosis assays, HDM-2 binding research, selective anti-cancer mechanisms |
| Synthesis | Solid-phase synthesis |
| Solubility | Soluble in water or 1% acetic acid |
| Stability & Storage | Stable for up to 24 months at -20°C. After reconstitution, may be stored at 4°C for up to 4 weeks or at -20°C for up to 6 months. |
| Appearance | White lyophilized powder |
| Shipping Conditions | Shipped at ambient temperature; once received, store at -20°C |
| Regulatory/Compliance | Manufactured in a facility that adheres to cGMP guidelines |
| Safety Information | Refer to provided MSDS |
3 reviews for PNC-27 30mg
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