FOX04-DRI 10mg (Proxofim)
Researched Benefits:
- Facilitates analysis of FOXO4-p53 interaction inhibition for investigating targeted senolysis
- Supports investigation into p53-mediated mitochondrial apoptosis in senescent cell assays
- Enables research on selective elimination of senescent fibroblasts and myofibroblasts
- Useful for evaluating homeostatic recovery and cellular rejuvenation in aging-related models
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Description
Description
FOXO4-DRI 10 mg (Proxofim)Â is a synthetic D-retro-inverso peptide engineered to disrupt the FOXO4-p53 interaction that allows senescent cells to resist apoptosis. By reinstating p53-mediated cell death in these cells, FOXO4-DRI functions as a potent senolytic agent in pre-clinical studies, opening new avenues for research into age-related degeneration and chronic inflammatory conditions.
Key Features:
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Manufactured under stringent cGMP-like conditions to ensure ≥99 % purity and batch-to-batch consistency.
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Lyophilized powder for maximum stability; reconstitutes rapidly in sterile distilled water or buffer.
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Extensively validated by HPLC and mass spectrometry for precise molecular integrity.
Applications:
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Investigating senolytic mechanisms and selective clearance of senescent cells.
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Exploring therapeutic potential in age-associated tissue dysfunction and metabolic decline.
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Assessing downstream effects on oxidative stress, insulin signaling, and cancer cell plasticity.
Specifications and Documentation
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Material Safety Data Sheet (MSDS):Â Coming Soon.
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Handling and Storage Instructions:Â Coming Soon.
FOXO4-DRI has emerged as a valuable research tool for probing cellular senescence, regenerative biology, and longevity science, offering investigators a robust platform for advancing anti-aging and disease-modifying strategies.
Additional information
| CAS No. | 2460055-10-9 |
|---|---|
| Purity | ≥99% |
| Sequence | D-(Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly) |
| Molecular Formula | C₂₂₈H₃₈₈N₈₆O₆₄ |
| Molecular Weight | 358.06 g/mol |
| Applications | Senescence research, anti-aging studies, degenerative disease models |
| Synthesis | Solid-phase synthesis |
| Solubility | Soluble in water or 1% acetic acid |
| Stability & Storage | Stable for up to 24 months at -20°C. After reconstitution, may be stored at 4°C for up to 4 weeks or at -20°C for up to 6 months. |
| Appearance | White lyophilized powder |
| Shipping Conditions | Shipped at ambient temperature; once received, store at -20°C |
| Regulatory/Compliance | Manufactured in a facility that adheres to cGMP guidelines |
| Safety Information | Refer to provided MSDS |
3 reviews for FOX04-DRI 10mg (Proxofim)
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